Clomid can also reduce the amount and quality of your cervical mucus. When exposed to estrogen, cervical mucus is thin and watery, which helps the sperm cells travel up to the fallopian tubes. When taking Clomid, estrogen levels are lower, causing the cervical mucus to be thicker than usual.
This can interfere with the ability of the sperm to get into the uterus and fallopian tubes. So far, there is no conclusive data that Clomid increases cancer risk in women. But there is some research suggesting a possible increase in endometrial cancer with the use of ovulation-inducing agents. To date, the research has not shown a significant risk for miscarriage, birth defects, or other pregnancy complications.
You should speak with your doctor about any specific concerns. It may just mean that you need a different form of treatment or that something additional is going on. Your doctor will likely suggest additional testing to identify these issues so they can be corrected before future treatment cycles. This process results from a complicated series of hormonal changes that occur in the beginning of her cycle.
This egg then travels down the fallopian tube where it may or may not be fertilized by a sperm cell. If the egg is fertilized, it may implant in the uterine lining and cause a pregnancy.
Without regular ovulation, it can become difficult to get pregnant. The odds of a woman getting pregnant by having sex while on her period are low, but not zero. FSH stimulates the growth of ovarian follicle and LH triggers the release of matured egg that travels down the fallopian tube.
Your doctor performs a battery of tests, before starting this drug therapy. Usually, a course of Clomid starts from the 2nd to 5th day of menstrual flow. A low dose of 50 mg daily for five days is the usual course up to 3 cycles. If ovulation doesn't happen in the first cycle, then it may be suggested to increase the dose for the next cycle.
You would also be closely monitored with some blood works and scans to know how your body responds to this drug therapy. When Is Clomid Used? Treatment Your doctor performs a battery of tests, before starting this drug therapy. Benefits Using Clomiphene citrate for treating infertility has a significant number of benefits such as: Cost-effective Being an oral medication, it's non-invasive treatment. Relatively fewer side effects Your regular OB-GYN or primary care provider can prescribe this drug, thus reducing the hassle of reaching to a reproductive specialist.
How severe PCOS can lead to infertility? Know More. What is Hydrosalpinx Removal? How does prolactin may impact fertility? When is Hysteroscopy Recommended Know More. By Marissa Conrad. Medically Reviewed Dr. Commissions we earn from partner links on this page do not affect our opinions or evaluations. Our editorial content is based on thorough research and guidance from the Forbes Health Advisory Board. Table of Contents What Is Clomid? How Does Clomid Work?
Who Should Take Clomid? What Is Clomid? Clomid is often prescribed for patients with: Unexplained infertility. American Society for Reproductive Medicine.
Irregular menstrual cycles. Polycystic ovary syndrome PCOS. Patients with PCOS often experience either infrequent periods or no periods at all and may be prescribed Clomid. However, U. Other potential side effects include: Ovarian enlargement Nausea and vomiting Breast discomfort Visual symptoms, including blurred vision or floaters small dark spots, lines or other shapes that seem to be floating in your line of vision Headaches Spotting Clomid and Chance of Multiples Taking Clomid increases the chance of carrying multiple babies.
Know Your Numbers Check your levels from the comfort of your own home. Footnotes Evidence-based treatments for couples with unexplained infertility: a guideline. LeFevre N. Follicle stimulating hormone predicts improvement in semen parameters with clomiphene citrate in men with infertility.
J Urology. Clomid clomiphene citrate tablets label. Food and Drug Administration. In most cases, patients are given an injection of hCG human chorionic gonadotropin also known as Ovidrel. This hormone initiates the release of the egg ovulation and the development of the corpus luteum, which will help the body to produce progesterone. Ovulation usually occurs approximately hours after the hCG injection.
After ovulation, a form of the hormone progesterone is given via vaginal tablets or gel in order to support the endometrial uterine lining and prepare it for the fertilized egg. Patients are asked to take a home pregnancy test urine test two weeks after ovulation. If the home test is positive, a blood test will be performed to confirm the results.
Clomiphene can sometimes decrease cervical mucus production, which may make it impossible for the sperm to swim through the cervix into the uterus. To get around this potential problem, intrauterine insemination IUI may be advised so that cervical mucus may be bypassed altogether.
If the lining is too thin, the embryo cannot implant successfully. This side effect tends to occur with repeated use or with higher doses of medication. Endometrial thinning will stop once clomiphene treatment concludes. An alternative therapy often recommended in these situations is a medication called Letrozole, which has a milder effect on the hormonal system.
Letrozole temporarily lowers estrogen levels, prompting the pituitary gland to increase FSH and LH production and promote ovulation. While letrozole is not yet FDA-approved for ovulation induction, widely conducted studies indicate that there is no detriment to this treatment option. This condition is rare in clomiphene treatment, and more common with use of gonadotropin medications.
Ovarian hyperstimulation syndrome is marked by abdominal bloating, nausea and diarrhea, and in more severe cases, symptoms including shortness of breath, difficulty with urination and chest pain. Adjustments can be made for those who hyperstimulate by decreasing medication and shortening the treatment cycle. The symptoms of hyperstimulation begin about a week after ovulation. Mild cases last about a week and usually respond to hydration and careful monitoring.
In general, ovarian hyperstimulation is highly unlikely, given careful monitoring of follicle development. Multiple pregnancy may be a risk with clomiphene treatment.
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