Studies in animals have shown some harmful effects on the fetus of a pregnant female given the drug. However, animal studies do not always predict what will happen in humans. Before you start using Byetta, let your doctor know if you are pregnant or think you could be pregnant.
If you are planning a pregnancy, talk with your doctor about the possible risks and benefits of using Byetta. If you would like to breastfeed while using Byetta, talk with your doctor about the possible risks and benefits. You can also call the American Association of Poison Control Centers at or use their online tool. But if your symptoms are severe, call or go to the nearest emergency room right away. If you have type 2 diabetes , your body has trouble controlling the level of sugar glucose in your blood.
This is because the cells in your body have built up a resistance to the effects of insulin. Insulin is the main hormone responsible for lowering your blood sugar levels. Over time, your body may also produce less insulin.
When you eat, your small intestine produces a hormone called GLP As the food starts to be absorbed into your blood, the level of glucose sugar in your blood starts to rise. GLP-1 stimulates your pancreas to release insulin into your bloodstream in response to the rise in blood sugar. Insulin directs cells in your body to remove glucose from your blood, and this lowers your blood sugar level. GLP-1 also has some other actions that help control your blood sugar.
It stops your pancreas from releasing a hormone called glucagon. Glucagon normally makes your liver produce glucose. If less glucagon is produced, it lowers your blood sugar level. In addition, GLP-1 also helps regulate your appetite. It slows down the speed that food moves through your stomach and into your small intestine.
This makes you feel fuller sooner. GLP-1 also acts in your brain to reduce your appetite. The active ingredient in Byetta is called exenatide. This is a type of drug called a glucagon-like peptide-1 GLP-1 receptor agonist. Byetta acts in a similar way to the hormone called GLP-1 that your intestine releases when you eat. This means it produces the same four effects as GLP These actions allow Byetta to help lower your blood sugar level after eating a meal and keep it lower between meals.
Byetta starts to work as soon as you inject a dose. It keeps building up an effect over the next couple of hours. Byetta has a similar effect to mealtime insulin fast-acting insulin because it makes your body produce more insulin in response to a meal. However, it also has other effects that help control your blood sugar between meals, as well as immediately after meals.
This depends on your individual situation. They may prescribe one of the many type 2 diabetes drugs that are now available, or they may prescribe insulin. Insulin can be used for both type 2 and type 1 diabetes. Byetta can be used along with a long-acting insulin such as insulin glargine. However, Byetta is not recommended for use with meal-time insulins.
Type 1 diabetes has to be treated with insulin injections. Byetta works primarily by making your pancreas produce more insulin. Byetta has other effects, such as making your stomach empty more slowly and helping you lose weight.
This means it could have potential as an add-on treatment for some people with type 1 diabetes. Those who might benefit include people whose blood sugar is not well controlled by insulin and people who could benefit from weight loss.
One study in type 1 diabetes found that adding Byetta to insulin improved blood sugar control more than insulin alone. However, exenatide was shown in one study to help with weight loss, improve insulin sensitivity the way cells respond to insulin , and encourage more regular periods in women with PCOS.
You could switch from Byetta to Bydureon if your doctor thinks it would work better for your specific health situation. Also, Bydureon could be more convenient because you only have to inject it once a week instead of twice a day. Before taking Byetta, talk with your doctor about your health history.
Byetta may not be right for you if you have certain medical conditions. These include:. Each Byetta package and pen will have an expiration date printed on it. The expiration date helps guarantee the medication is effective during this time. If you have unused medication that has gone past the expiration date, talk to your pharmacist about whether you might still be able to use it. Each Byetta pen can be used for 30 days.
If there is medication left in the pen 30 days after you first use it, safely dispose of it in a sharps disposal container. How long a medication remains good can depend on many factors, including how and where you store it. Keep it in the box it came in. Avoid freezing your pens. Always remove the needle and put the pen cap back on after you inject a dose of Byetta.
The cap protects the drug from light. This helps prevent others, including children and pets, from taking the drug by accident. It also helps keep the drug from harming the environment. The FDA website provides several useful tips on medication disposal. You can also ask your pharmacist how to dispose of your medication. Byetta is FDA-approved to help control blood glucose levels in adult patients with type 2 diabetes , as an adjunct to diet and exercise.
Byetta has been studied as monotherapy for type 2 diabetes. Byetta should not be prescribed to control blood sugar in type 1 diabetes or diabetic ketoacidosis.
Byetta contains exenatide, a glucagon-like peptide-1 GLP-1 receptor agonist or incretin mimetic. It activates the GLP-1 receptor on beta cells in the pancreas, stimulating insulin release in response to rising glucose levels and reducing the release of glucagon. In addition, Byetta slows down gastric emptying, thereby reducing the rate at which mealtime glucose is absorbed into the bloodstream.
It reduces appetite and intake of food. Byetta increases first-phase and second-phase insulin response and reduces postprandial and fasting glucose levels. Byetta has similar bioavailability when administered in the thigh, abdomen, or upper arm. It reaches median peak plasma concentration in 2. Byetta is mainly renally excreted through glomerular filtration.
It has a mean terminal half-life of 2. The pharmacokinetics of Byetta are not affected by age. Byetta should not be used in people who have had a hypersensitivity reaction to exenatide or any of the excipients. Byetta should also not be used in people with a history of immune-mediated thrombocytopenia caused by exenatide. When not in use, pens should be stored without a needle attached and with the cap on. Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date.
However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.
The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Find out here about the differences and…. Many people have misconceptions about type 2 diabetes.
In this article, we discuss five of the common myths surrounding this condition and provide the…. Insulin helps the body use glucose to produce energy. Insulin resistance occurs when excess sugar circulates in the body. Over time, it can lead to…. While specialists do not recommend a specific diet for diabetes, research has shown that people who follow a ketogenic diet can improve the management….
Junk foods often contain high levels of saturated fats and sugars. These can result in sugar spikes and weight gain, and a higher risk of diabetes…. Byetta exenatide. Bydureon Byetta vs. Byetta generic. Byetta dosage. Byetta side effects. Byetta cost. Alternatives to Byetta. Byetta vs. Outcome Measures. Primary Outcome Measures : Energy Intake [ Time Frame: Day at baseline and Day 3 days after starting study intervention ] Mean of 3-day food intake change between 3 days Day at baseline assessment and 3 days Day during the intervention period between the exenatide and placebo groups.
Change of twenty-four-hour energy expenditure between at Day 5 at baseline assessment and at Day 11 two days after starting study medication between the exenatide and placebo groups. Secondary Outcome Measures : Body Weight [ Time Frame: 5 weeks ] Mean decrease between pre- and post-randomization in 5 Weeks between the exenatide and placebo groups.
Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision.
Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials. More Information. Metabolic effects of two years of exenatide treatment on diabetes, obesity, and hepatic biomarkers in patients with type 2 diabetes: an interim analysis of data from the open-label, uncontrolled extension of three double-blind, placebo-controlled trials.
Clin Ther. Effects of exenatide exendin-4 on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes. Diabetes Care. Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis. J Clin Endocrinol Metab. Cognitive dietary restraint, disinhibition, and hunger are associated with h energy expenditure. Int J Obes Lond. Epub Jan Exenatide has a pronounced effect on energy intake but not energy expenditure in non-diabetic subjects with obesity: A randomized, double-blind, placebo-controlled trial.
Epub Mar National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services.
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. The GLP-1 class of drugs isn't recommended if you have a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia. Laboratory studies have linked these drugs with thyroid tumors in rats, but until more long-term studies are completed, the risk to humans isn't known.
They're also not recommended if you've had pancreatitis. The drugs already discussed are designed for people who have type 2 diabetes. There is also a drug that contains a higher dose of liraglutide Saxenda that's approved for the treatment of obesity in people who don't have diabetes. If you have diabetes and wonder if one of these drugs may be helpful for you, talk to your doctor. There is a problem with information submitted for this request. Sign up for free, and stay up-to-date on research advancements, health tips and current health topics, like COVID, plus expert advice on managing your health.
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Are there any type 2 diabetes drugs that can help people lose weight and lower their blood sugar? Are there side effects? Answer From M.
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